Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor

We investigated the mechanism whereby cell contact injury stimulates the α-smooth muscle actin (SMA) promoter, a key process for epithelial–mesenchymal transition (EMT) during organ fibrosis. Contact disruption by low-Ca(2+) medium (LCM) activated Rac, PAK and p38 MAPK, and triggered the nuclear acc...

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Publicat a:FEBS Lett
Autors principals: Sebe, Attila, Masszi, András, Zulys, Matthew, Yeung, Tony, Speight, Pam, Rotstein, Ori. D., Nakano, Hiroyasu, Mucsi, István, Szászi, Katalin, Kapus, András
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047756/
https://ncbi.nlm.nih.gov/pubmed/18154735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.12.021
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