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Bayesian Optimal Interval Design: A Simple and Well-Performing Design for Phase I Oncology Trials

Despite more than two decades of publications that offer more innovative model-based designs, the classical 3+3 design remains the most dominant phase I trial design in practice. In this article, we introduce a new trial design, the Bayesian optimal interval (BOIN) design. The BOIN design is easy to...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Yuan, Ying, Hess, Kenneth R., Hilsenbeck, Susan G., Gilbert, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047439/
https://ncbi.nlm.nih.gov/pubmed/27407096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0592
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