Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver–Russell syndrome phenotypes

Genomic imprinting affects a subset of genes in mammals, such that they are expressed in a monoallelic, parent-of-origin–specific manner. These genes are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-specific differential DNA methylation. Although genomi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hur, Stella K., Freschi, Andrea, Ideraabdullah, Folami, Thorvaldsen, Joanne L., Luense, Lacey J., Weller, Angela H., Berger, Shelley L., Cerrato, Flavia, Riccio, Andrea, Bartolomei, Marisa S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047210/
https://ncbi.nlm.nih.gov/pubmed/27621468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603066113
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