Structural characterization of a flexible two-domain protein in solution using Small Angle X-ray Scattering and NMR spectroscopy

Multidomain proteins in which individual domains are connected by linkers often possess inherent inter-domain flexibility that significantly complicates their structural characterization in solution using either NMR spectroscopy or small-angle X-ray scatting (SAXS) alone. Here we report a novel prot...

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Pubblicato in:Structure
Autori principali: Lemak, Alexander, Wu, Bin, Yee, Adelinda, Houliston, Scott, Lee, Hsiau-Wei, Gutmanas, Aleksandras, Fang, Xianyang, Garcia, Maite, Semesi, Anthony, Wang, Yun-Xing, Prestegard, James H., Arrowsmith, Cheryl H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046226/
https://ncbi.nlm.nih.gov/pubmed/25456817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.013
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