The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

BACKGROUND: The formation of new lymphatic vessels provides an additional route for tumour cells to metastasize. Therefore, inhibiting lymphangiogenesis represents an interesting target in cancer therapy. First evidence suggests that histone deacetylase inhibitors (HDACi) may mediate part of their a...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Hrgovic, Igor, Doll, Monika, Kleemann, Johannes, Wang, Xiao-Fan, Zoeller, Nadja, Pinter, Andreas, Kippenberger, Stefan, Kaufmann, Roland, Meissner, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045659/
https://ncbi.nlm.nih.gov/pubmed/27716272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2807-y
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