The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

BACKGROUND: The formation of new lymphatic vessels provides an additional route for tumour cells to metastasize. Therefore, inhibiting lymphangiogenesis represents an interesting target in cancer therapy. First evidence suggests that histone deacetylase inhibitors (HDACi) may mediate part of their a...

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Publicat a:BMC Cancer
Autors principals: Hrgovic, Igor, Doll, Monika, Kleemann, Johannes, Wang, Xiao-Fan, Zoeller, Nadja, Pinter, Andreas, Kippenberger, Stefan, Kaufmann, Roland, Meissner, Markus
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045659/
https://ncbi.nlm.nih.gov/pubmed/27716272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2807-y
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