Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR– tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and LC–MS/MS following i.v. administration of BMS-75349...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Shen, Hong, Wang, Lifei, Chen, Weiqi, Menard, Krista, Hong, Yang, Tian, Yuan, Bonacorsi, Samuel J., Humphreys, W. Griffith, Lee, Francis Y., Gan, Jinping
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045555/
https://ncbi.nlm.nih.gov/pubmed/27709015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.07.009
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