The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2

Up-regulation of anti-apoptotic factors is a critical mechanism of cancer cell resistance and often counteracts the success of chemotherapeutic treatment. Herein, we identified the cancer-associated RNA-binding protein La as novel factor contributing to cisplatin resistance. Our data demonstrate tha...

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Vydáno v:Oncotarget
Hlavní autoři: Heise, Tilman, Kota, Venkatesh, Brock, Alexander, Morris, Amanda B., Rodriguez, Reycel M., Zierk, Avery W., Howe, Philip H., Sommer, Gunhild
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045424/
https://ncbi.nlm.nih.gov/pubmed/27105491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8819
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