Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation

Hepatitis C virus (HCV) infection reorganizes cellular membranes to create an active viral replication site named the membranous web (MW). The role that human choline kinase-α (hCKα) plays in HCV replication remains elusive. Here, we first showed that hCKα activity, not the CDP-choline pathway, prom...

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Vydáno v:J Virol
Hlavní autoři: Wong, Mun-Teng, Chen, Steve S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044849/
https://ncbi.nlm.nih.gov/pubmed/27489281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00960-16
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