Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA

Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from chronic hepatitis B virus (HBV) infection. Recently, methylation has been identified as a novel host defense mechanism, and methylation of viral DNA leads to downregulation of HBV gene expression. To bett...

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Autors principals: Vivekanandan, Perumal, Daniel, Hubert Darius-J, Kannangai, Rajesh, Martinez-Murillo, Francisco, Torbenson, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863779/
https://ncbi.nlm.nih.gov/pubmed/20147412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02280-09
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