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Asymmetric synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives via sequential palladium and copper catalysis

We present a full account detailing the development of a sequential catalysis strategy for the synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives. A palladium-catalyzed cross coupling of terminal alkyne donors with acetylenic ester, ketone, and sulfone acceptors generates stereodefined...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Trost, Barry M., Masters, James T., Taft, Benjamin R., Lumb, Jean-Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044515/
https://ncbi.nlm.nih.gov/pubmed/27746892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc01724j
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