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Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice
In order to treat progressive paralysis in ALS patients, it is critical to develop a mouse that closely models human ALS in both pathology and also in the timing of these events. We have recently generated new TDP-43 bigenic mice (called rNLS8) with doxycycline (Dox)-suppressible expression of human...
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| Pubblicato in: | Acta Neuropathol Commun |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5043606/ https://ncbi.nlm.nih.gov/pubmed/27687289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0377-5 |
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