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EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2–Mediated Renal Water Reabsorption

Nephrogenic diabetes insipidus (NDI) is caused by impairment of vasopressin (VP) receptor type 2 signaling. Because potential therapies for NDI that target the canonical VP/cAMP/protein kinase A pathway have so far proven ineffective, alternative strategies for modulating aquaporin 2 (AQP2) traffick...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Cheung, Pui W., Nomura, Naohiro, Nair, Anil V., Pathomthongtaweechai, Nutthapoom, Ueberdiek, Lars, Lu, Hua A. Jenny, Brown, Dennis, Bouley, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042667/
https://ncbi.nlm.nih.gov/pubmed/27694161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080903
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