High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration

A reduction or loss of plasma membrane aquaporin 2 (AQP2) in kidney principal cells due to defective vasopressin (VP) signaling through the VP receptor causes excessive urine production, i.e., diabetes insipidus. The amount of AQP2 on the plasma membrane is regulated by a balance of exocytosis and e...

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Main Authors: Nomura, Naohiro, Nunes, Paula, Bouley, Richard, Nair, Anil V., Shaw, Stanley, Ueda, Erica, Pathomthongtaweechai, Nutthapoom, Lu, Hua A. Jenny, Brown, Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Methods in Cell Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187055/
https://ncbi.nlm.nih.gov/pubmed/24944200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00154.2014
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