High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration

A reduction or loss of plasma membrane aquaporin 2 (AQP2) in kidney principal cells due to defective vasopressin (VP) signaling through the VP receptor causes excessive urine production, i.e., diabetes insipidus. The amount of AQP2 on the plasma membrane is regulated by a balance of exocytosis and e...

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Bibliografische gegevens
Hoofdauteurs: Nomura, Naohiro, Nunes, Paula, Bouley, Richard, Nair, Anil V., Shaw, Stanley, Ueda, Erica, Pathomthongtaweechai, Nutthapoom, Lu, Hua A. Jenny, Brown, Dennis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2014
Onderwerpen:
Methods in Cell Physiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187055/
https://ncbi.nlm.nih.gov/pubmed/24944200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00154.2014
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