Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues

OBJECTIVE: IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to reduce weight gain in mice. Contrarily, our findings on IL-15 knockout (KO) mice indicate that IL-15 promotes obesity. The aim of this...

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Udgivet i:PLoS One
Main Authors: Lacraz, Gregory, Rakotoarivelo, Volatiana, Labbé, Sebastien M., Vernier, Mathieu, Noll, Christophe, Mayhue, Marian, Stankova, Jana, Schwertani, Adel, Grenier, Guillaume, Carpentier, André, Richard, Denis, Ferbeyre, Gerardo, Fradette, Julie, Rola-Pleszczynski, Marek, Menendez, Alfredo, Langlois, Marie-France, Ilangumaran, Subburaj, Ramanathan, Sheela
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042499/
https://ncbi.nlm.nih.gov/pubmed/27684068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162995
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