The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level

The Yes-associated protein, YAP, is a transcriptional co-activator, mediating the Epithelial to Mesenchymal Transition program in pancreatic ductal adenocarcinoma (PDAC). With the aim to identify compounds that can specifically modulate YAP functionality in PDAC cell lines, we performed a small scal...

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Publicado en:Oncotarget
Autores principales: Thongon, Natthakan, Castiglioni, Ilaria, Zucal, Chiara, Latorre, Elisa, D'Agostino, Vito, Bauer, Inga, Pancher, Michael, Ballestrero, Alberto, Feldmann, Georg, Nencioni, Alessio, Provenzani, Alessandro
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041998/
https://ncbi.nlm.nih.gov/pubmed/27034169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8437
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