EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD(+) biosynthesis from nicotinamide, is one of the major factors regulating cancer cells metabolism and is considered a promising target for treating cancer. The prototypical NAMPT inhibitor FK866 effectively l...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Zucal, Chiara, D’Agostino, Vito G., Casini, Antonio, Mantelli, Barbara, Thongon, Natthakan, Soncini, Debora, Caffa, Irene, Cea, Michele, Ballestrero, Alberto, Quattrone, Alessandro, Indraccolo, Stefano, Nencioni, Alessio, Provenzani, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636066/
https://ncbi.nlm.nih.gov/pubmed/26542945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1845-1
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