Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Activation of hypoxia-inducible factor (HIF) and macrophage infiltration of solid tumors independently promote tumor progression. As little is known how myeloid HIF affects tumor development, we injected the polycyclic aromatic hydrocarbon (PAH) and procarcinogen 3-methylcholanthrene (MCA; 100 μg/10...

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Vydáno v:Oncotarget
Hlavní autoři: Henke, Nina, Ferreirós, Nerea, Geisslinger, Gerd, Ding, Martina G., Essler, Silke, Fuhrmann, Dominik C., Geis, Theresa, Namgaladze, Dmitry, Dehne, Nathalie, Brüne, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041954/
https://ncbi.nlm.nih.gov/pubmed/27015123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8297
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