Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model

Activation of hypoxia-inducible factor (HIF) and macrophage infiltration of solid tumors independently promote tumor progression. As little is known how myeloid HIF affects tumor development, we injected the polycyclic aromatic hydrocarbon (PAH) and procarcinogen 3-methylcholanthrene (MCA; 100 μg/10...

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Udgivet i:Oncotarget
Main Authors: Henke, Nina, Ferreirós, Nerea, Geisslinger, Gerd, Ding, Martina G., Essler, Silke, Fuhrmann, Dominik C., Geis, Theresa, Namgaladze, Dmitry, Dehne, Nathalie, Brüne, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041954/
https://ncbi.nlm.nih.gov/pubmed/27015123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8297
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