Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promo...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Unruh, Dusten, Ünlü, Betül, Lewis, Clayton S., Qi, Xiaoyang, Chu, Zhengtao, Sturm, Robert, Keil, Ryan, Ahmad, Syed A., Sovershaev, Timofey, Adam, Mariette, Van Dreden, Patrick, Woodhams, Barry J., Ramchandani, Divya, Weber, Georg F., Rak, Janusz W., Wolberg, Alisa S., Mackman, Nigel, Versteeg, Henri H., Bogdanov, Vladimir Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041902/
https://ncbi.nlm.nih.gov/pubmed/26967388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7955
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