Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Unruh, Dusten, Ünlü, Betül, Lewis, Clayton S., Qi, Xiaoyang, Chu, Zhengtao, Sturm, Robert, Keil, Ryan, Ahmad, Syed A., Sovershaev, Timofey, Adam, Mariette, Van Dreden, Patrick, Woodhams, Barry J., Ramchandani, Divya, Weber, Georg F., Rak, Janusz W., Wolberg, Alisa S., Mackman, Nigel, Versteeg, Henri H., Bogdanov, Vladimir Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041902/
https://ncbi.nlm.nih.gov/pubmed/26967388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7955
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