Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21(Cip1/Waf1) Pathway

In the present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) of the 3rd passage displayed the senescence-associated phenotypes characterized with increased activity of SA-β-gal, altered autophagy, and increased G1 cell cycle arrest, ROS production, and expression of p53 and...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Zhang, Mingyu, Du, Yue, Lu, Renzhong, Shu, You, Zhao, Wei, Li, Zhuoyun, Zhang, Yu, Liu, Ruixue, Yang, Ti, Luo, Shenjian, Gao, Ming, Zhang, Yue, Zhang, Guiye, Liu, Jiaqi, Lu, Yanjie
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040816/
https://ncbi.nlm.nih.gov/pubmed/27703600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7524308
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