Three-dimensional study of Alzheimer's disease hallmarks using the iDISCO clearing method

Amyloidosis is a major problem in over one hundred diseases including Alzheimer's disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing and light-sheet microscopy, we studied plaque formation in the intact AD mouse brain and up to twenty-seve...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Liebmann, Thomas, Renier, Nicolas, Bettayeb, Karima, Greengard, Paul, Tessier-Lavigne, Marc, Flajolet, Marc
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040352/
https://ncbi.nlm.nih.gov/pubmed/27425620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.060
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