PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Neuroinflammation
Päätekijät: Rom, Slava, Zuluaga-Ramirez, Viviana, Reichenbach, Nancy L., Dykstra, Holly, Gajghate, Sachin, Pacher, Pal, Persidsky, Yuri
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2016
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039899/
https://ncbi.nlm.nih.gov/pubmed/27677851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0729-x
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