PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Rom, Slava, Zuluaga-Ramirez, Viviana, Reichenbach, Nancy L., Dykstra, Holly, Gajghate, Sachin, Pacher, Pal, Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039899/
https://ncbi.nlm.nih.gov/pubmed/27677851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0729-x
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