PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory...

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Publicado en:J Neuroinflammation
Autores principales: Rom, Slava, Zuluaga-Ramirez, Viviana, Reichenbach, Nancy L., Dykstra, Holly, Gajghate, Sachin, Pacher, Pal, Persidsky, Yuri
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039899/
https://ncbi.nlm.nih.gov/pubmed/27677851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0729-x
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