Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity

Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012, monthly DP for 1 year decreased the incidence...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Nankabirwa, Joaniter I., Conrad, Melissa D., Legac, Jennifer, Tukwasibwe, Stephen, Tumwebaze, Patrick, Wandera, Bonnie, Brooker, Simon J., Staedke, Sarah G., Kamya, Moses R., Nsobya, Sam L., Dorsey, Grant, Rosenthal, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Epidemiology and Surveillance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038325/
https://ncbi.nlm.nih.gov/pubmed/27401569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00920-16
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