Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα

Encephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, both in vitro and in cell...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dorobantu, Cristina M., Harak, Christian, Klein, Rahel, van der Linden, Lonneke, Strating, Jeroen R. P. M., van der Schaar, Hilde M., Lohmann, Volker, van Kuppeveld, Frank J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038282/
https://ncbi.nlm.nih.gov/pubmed/27480860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01331-16
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