Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

Positive-strand RNA [(+)RNA] viruses are true masters of reprogramming host lipid trafficking and synthesis to support virus genome replication. Via their membrane-associated 3A protein, picornaviruses of the genus Enterovirus (e.g., poliovirus, coxsackievirus, and rhinovirus) subvert Golgi complex-...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Dorobantu, Cristina M., Albulescu, Lucian, Lyoo, Heyrhyoung, van Kampen, Mirjam, De Francesco, Raffaele, Lohmann, Volker, Harak, Christian, van der Schaar, Hilde M., Strating, Jeroen R. P. M., Gorbalenya, Alexander E., van Kuppeveld, Frank J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888891/
https://ncbi.nlm.nih.gov/pubmed/27303747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00068-16
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