Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

The plant defensin NaD1 is a potent antifungal molecule that also targets tumor cells with a high efficiency. We examined the features of NaD1 that contribute to these two activities by producing a series of chimeras with NaD2, a defensin that has relatively poor activity against fungi and no activi...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Bleackley, Mark R., Payne, Jennifer A. E., Hayes, Brigitte M. E., Durek, Thomas, Craik, David J., Shafee, Thomas M. A., Poon, Ivan K. H., Hulett, Mark D., van der Weerden, Nicole L., Anderson, Marilyn A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038239/
https://ncbi.nlm.nih.gov/pubmed/27503651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01479-16
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