Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

The plant defensin NaD1 is a potent antifungal molecule that also targets tumor cells with a high efficiency. We examined the features of NaD1 that contribute to these two activities by producing a series of chimeras with NaD2, a defensin that has relatively poor activity against fungi and no activi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bleackley, Mark R., Payne, Jennifer A. E., Hayes, Brigitte M. E., Durek, Thomas, Craik, David J., Shafee, Thomas M. A., Poon, Ivan K. H., Hulett, Mark D., van der Weerden, Nicole L., Anderson, Marilyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038239/
https://ncbi.nlm.nih.gov/pubmed/27503651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01479-16
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