Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant

The plant defensin NaD1 is a potent antifungal molecule that also targets tumor cells with a high efficiency. We examined the features of NaD1 that contribute to these two activities by producing a series of chimeras with NaD2, a defensin that has relatively poor activity against fungi and no activi...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Bleackley, Mark R., Payne, Jennifer A. E., Hayes, Brigitte M. E., Durek, Thomas, Craik, David J., Shafee, Thomas M. A., Poon, Ivan K. H., Hulett, Mark D., van der Weerden, Nicole L., Anderson, Marilyn A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038239/
https://ncbi.nlm.nih.gov/pubmed/27503651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01479-16
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