Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice

Cytokines play key roles in spontaneous CD4(+) T cell–mediated chronic autoimmune arthritis in SKG mice, a new model of rheumatoid arthritis. Genetic deficiency in IL-6 completely suppressed the development of arthritis in SKG mice, irrespective of the persistence of circulating rheumatoid factor. E...

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Detalhes bibliográficos
Main Authors: Hata, Hiroshi, Sakaguchi, Noriko, Yoshitomi, Hiroyuki, Iwakura, Yoichiroh, Sekikawa, Kenji, Azuma, Yoshiaki, Kanai, Chieko, Moriizumi, Eiko, Nomura, Takashi, Nakamura, Takashi, Sakaguchi, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503774/
https://ncbi.nlm.nih.gov/pubmed/15314695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421795
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