Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid Culture

Androgen receptor (AR) targeting remains the gold standard treatment for advanced prostate cancer (PCa); however, treatment resistance remains a major clinical problem. To study the therapeutic effects of clinically used anti-androgens we characterized herein a tissue-mimetic three-dimensional (3D)...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Eder, Theresa, Weber, Anja, Neuwirt, Hannes, Grünbacher, Georg, Ploner, Christian, Klocker, Helmut, Sampson, Natalie, Eder, Iris E.
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037737/
https://ncbi.nlm.nih.gov/pubmed/27598125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17091458
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