Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions

Carcinoma‐associated fibroblasts (CAFs) play a key onco‐supportive role during prostate cancer (PCa) development and progression. We previously reported that the reactive oxygen species (ROS)‐producing enzyme NADPH oxidase 4 (Nox4) is essential for TGFβ1‐mediated activation of primary prostate human...

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Detalles Bibliográficos
Publicado en:Int J Cancer
Autores principales: Sampson, Natalie, Brunner, Elena, Weber, Anja, Puhr, Martin, Schäfer, Georg, Szyndralewiez, Cedric, Klocker, Helmut
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Tumor Immunology and Microenvironment
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067067/
https://ncbi.nlm.nih.gov/pubmed/29441570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31316
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