Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

BACKGROUND: Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clinical management of patients, also because the molecular mechanisms behind thera...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Neuwirt, Hannes, Bouchal, Jan, Kharaishvili, Gvantsa, Ploner, Christian, Jöhrer, Karin, Pitterl, Florian, Weber, Anja, Klocker, Helmut, Eder, Iris E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979368/
https://ncbi.nlm.nih.gov/pubmed/31980029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0505-5
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