Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migrati...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Binamé, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037408/
https://ncbi.nlm.nih.gov/pubmed/27646271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201601063
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