Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migrati...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Binamé, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037408/
https://ncbi.nlm.nih.gov/pubmed/27646271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201601063
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