Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migrati...

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Bibliografski detalji
Izdano u:J Cell Biol
Glavni autori: Binamé, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037408/
https://ncbi.nlm.nih.gov/pubmed/27646271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201601063
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