Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migrati...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Cell Biol
Auteurs principaux: Binamé, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2016
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037408/
https://ncbi.nlm.nih.gov/pubmed/27646271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201601063
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