Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration

Spatiotemporal regulation of RhoGTPases such as RhoA is required at the cell leading edge to achieve cell migration. p190RhoGAP (p190A) is the main negative regulator of RhoA and localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for directional migrati...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Binamé, Fabien, Bidaud-Meynard, Aurélien, Magnan, Laure, Piquet, Léo, Montibus, Bertille, Chabadel, Anne, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037408/
https://ncbi.nlm.nih.gov/pubmed/27646271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201601063
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