Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry

Anthrax toxin comprises three soluble proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA must be cleaved by host proteases before it oligomerizes and forms a prepore, to which LF and EF bind. After endocytosis of this tripartite complex, the prepore transforms into a na...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Fabre, Lucien, Santelli, Eugenio, Mountassif, Driss, Donoghue, Annemarie, Biswas, Aviroop, Blunck, Rikard, Hanein, Dorit, Volkmann, Niels, Liddington, Robert, Rouiller, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037343/
https://ncbi.nlm.nih.gov/pubmed/27670897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611617
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