A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin
Current evidence favors the theory that, when the globular motor domain of myosin attaches to actin, the light chain binding domain or “lever arm” rotates, and thereby generates movement of actin filaments. Myosin is uniquely designed for such a role in that a long α-helix (≈9 nm) extending from the...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC503728/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15256600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401699101 |
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