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A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin

Current evidence favors the theory that, when the globular motor domain of myosin attaches to actin, the light chain binding domain or “lever arm” rotates, and thereby generates movement of actin filaments. Myosin is uniquely designed for such a role in that a long α-helix (≈9 nm) extending from the...

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Autori principali: Sherwood, Jennifer J., Waller, Guillermina S., Warshaw, David M., Lowey, Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC503728/
https://ncbi.nlm.nih.gov/pubmed/15256600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401699101
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