Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells

Weak and ineffective antitumor cytotoxic T lymphocyte (CTL) responses can be rescued by immunomodulatory monoclonal antibodies (mAbs) targeting PD-1 or CD137. Using Batf3(-/-) mice, which are defective for cross-presentation of cell-associated antigens, we show that Batf3-dependent dendritic cells (...

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Publicado no:Cancer Discov
Main Authors: Sánchez-Paulete, Alfonso R., Cueto, Francisco J., Martínez-López, María, Labiano, Sara, Morales-Kastresana, Aizea, Rodríguez-Ruiz, María E., Jure-Kunkel, Maria, Azpilikueta, Arantza, Aznar, M. Angela, Quetglas, José I., Sancho, David, Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036540/
https://ncbi.nlm.nih.gov/pubmed/26493961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0510
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