Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive liver disease, termed nonalcoholic steatohepatitis, which is characterized by hepatocellular apoptosis and innate immune...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Hirsova, Petra, Ibrabim, Samar H., Gores, Gregory J., Malhi, Harmeet
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2016
Subjects:
Thematic Review Series
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036373/
https://ncbi.nlm.nih.gov/pubmed/27049024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R066357
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