Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis

Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of bile acids in hepatic i...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Liu, Hailiang, Pathak, Preeti, Boehme, Shannon, Chiang, John Y. L.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2016
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036364/
https://ncbi.nlm.nih.gov/pubmed/27534992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M069807
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