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Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

Cholesterol 7α-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. In addition to absorption and digestion of nutrients, bile acids play a critical role in the regulation of lipid, glucose, and energy homeostasis. We have backcrosse...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Ferrell, Jessica M., Boehme, Shannon, Li, Feng, Chiang, John Y. L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918844/
https://ncbi.nlm.nih.gov/pubmed/27146480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M064709
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