Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

OBJECTIVE: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. DESIGN: We assessed the expression of...

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Vydáno v:Gut
Hlavní autoři: Fischer, Anika, Zundler, Sebastian, Atreya, Raja, Rath, Timo, Voskens, Caroline, Hirschmann, Simon, López-Posadas, Rocío, Watson, Alastair, Becker, Christoph, Schuler, Gerold, Neufert, Clemens, Atreya, Imke, Neurath, Markus F
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2016
Témata:
Inflammatory Bowel Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036234/
https://ncbi.nlm.nih.gov/pubmed/26209553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310022
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