Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

OBJECTIVE: Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn’s disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF ther...

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Detaylı Bibliyografya
Yayımlandı:Gut
Asıl Yazarlar: Schmitt, Heike, Billmeier, Ulrike, Dieterich, Walburga, Rath, Timo, Sonnewald, Sophia, Reid, Stephen, Hirschmann, Simon, Hildner, Kai, Waldner, Maximilian J, Mudter, Jonas, Hartmann, Arndt, Grützmann, Robert, Neufert, Clemens, Münster, Tino, Neurath, Markus F, Atreya, Raja
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMJ Publishing Group 2019
Konular:
Inflammatory Bowel Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580782/
https://ncbi.nlm.nih.gov/pubmed/29848778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-315671
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