Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex

Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac hypertrophy and fibrosis. The regulatory mechanism...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yang, Jin, Feng, Xuhui, Zhou, Qiong, Cheng, Wei, Shang, Ching, Han, Pei, Lin, Chiou-Hong, Chen, Huei-Sheng Vincent, Quertermous, Thomas, Chang, Ching-Pin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035905/
https://ncbi.nlm.nih.gov/pubmed/27601681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525078113
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