TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Corticostriatal atrophy is a cardinal manifestation of Huntington’s disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein contributes to the degeneration of the corticostriatal circuit is not well understood. We recreated the corticostriatal circuit in microfluidic chambe...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
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PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035849/
https://ncbi.nlm.nih.gov/pubmed/27601642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603020113
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